Background.MicroRNA-10a (miR-10a) inhibits transcriptional factor GATA6 to repress inflammatory GATA6/VCAM-1 signaling, which is regulated by blood flow to affect endothelial function/dysfunction.This study aimed to identify the expression patterns of miR-10a/GATA6/VCAM-1 in vivo and study their implications in the pathophysiology of human coronary
Presumed late recurrence of Acanthamoeba keratitis exacerbated by exposure to topical corticosteroids
A 28-year-old female with a history of contact lens wear presented with a 1 week history of pain and photophobia in her left eye.In vivo confocal microscopy (IVCM) and corneal scrape confirmed the diagnosis of Acanthamoeba keratitis (AK) which was treated with intensive topical propamidine isethionate (0.1%) and chlorhexidine (0.02%) with tapering
Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis
Abstract Background Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections.How such tolerance is acquired is not well understood but is known to involve epigenetic and transcriptional dysregulation.Methods Bead arrays were used to c
Tracing the Genetic Evolution of Canine Parvovirus Type 2 (CPV-2) in Thailand
Canine parvovirus type 2 (CPV-2) is responsible for hemorrhagic gastroenteritis in Course a pied - Homme - Vetements - Short - Cuissard dogs worldwide.High genomic substitution rates in CPV-2 contribute to the progressive emergence of novel variants with increased ability to evade the host immune response.Three studies have analyzed the genomic mut